| Sunday 10/04/2022 | T20 Game | Bailliefields | 12:00 |
| Saturday 23/04/2022 | Kirk Brae (F) | Bailliefields | 12:00 |
| Saturday 30/04/2022 | Dunfermline & Carnegie | Bailliefields | 13:00 |
| Saturday 07/05/2022 | Hawick & Wilton | Buccleuch Park | 13:00 |
| Saturday 14/05/2022 | Edinburgh Accies 2 | Bailliefields | 13:00 |
| Saturday 21/05/2022 | Stewarts Melville 2 | Inverleith (grass) | 13:00 |
| Sunday 22/05/2022 | Linlithgow (ESCA Dev - 30 overs) | Boghall | 13:30 |
| Saturday 28/05/2022 | Royal High Corstorphine 2 | Bailliefields | 13:00 |
| Saturday 04/06/2022 | Kirk Brae | Double Hedges | 13:00 |
| Saturday 11/06/2022 | Edinburgh CC 2 | Bailliefields | 13:00 |
| Sunday 12/06/2022 | Comrie (F) | Comrie CANCELLED | tbc |
| Sunday 19/06/2022 | Dunfermline & Carnegie (ESCA Dev) | Bailliefields | 13:00 |
| Sunday 19/06/2022 | Carlton 3 | Grange Loan | 13:00 |
| Tuesday 21/06/2022 | Paktoon Warriors (T20) | Bailliefields | 18:00 |
| Saturday 25/06/2022 | Boroughmuir | Meggetland | 13:00 |
| Saturday 02/07/2022 | Dunfermline & Carnegie | McKane Park | 13:00 |
| Saturday 09/07/2022 | Hawick & Wilton | Bailliefields | 13:00 |
| Sunday 10/07/2022 | Kinross (F) | Kinross | 12:00 |
| Saturday 16/07/2022 | Edinburgh Accies 2 | Newfield (artificial) | 13:00 |
| Sunday 17/07/2022 | Clydesdale (F) | Bailliefields | 13:00 |
| Saturday 23/07/2022 | Stewarts Melville 2 | Bailliefields | 13:00 |
| Sunday 24/07/2022 | Doune (F) | Doune | 12:00 |
| Saturday 30/07/2022 | Royal High Corstorphine 2 | Royal High School | 13:00 |
| Saturday 06/08/2022 | Kirk Brae | Bailliefields | 13:00 |
| Saturday 13/08/2022 | Edinburgh CC 2 | Campbell Park | 13:00 |
| Sunday 14/08/2022 | Carlton (ESCA Dev) | Grange Loan | 13:00 |
| Saturday 20/08/2022 | Carlton 3 | Bailliefields | 13:00 |
| Saturday 27/08/2022 | Boroughmuir | Bailliefields | 13:00 |
| Saturday 10/09/2022 | Broomhall (ESCA Dev) | Bailliefields | 13:00 |
